Azidothymidine (AZT), also known as zidovudine (ZDV), is an antiretroviral drug primarily used to treat and prevent HIV/AIDS. It works by inhibiting the reverse transcriptase enzyme, which HIV uses to replicate, thus decreasing the virus's replication rate. 
 
Key points about azidothymidine:
  • Mechanism of Action:
    AZT is a nucleoside reverse transcriptase inhibitor (NRTI) that interferes with the HIV reverse transcriptase enzyme, halting the virus's ability to create new viral DNA. 
     
  • Uses:
    AZT is used to treat HIV infection and prevent the transmission of HIV from mother to child during pregnancy and birth. It can also be used after a needlestick injury or other potential exposure to HIV. 
     
  • Combination Therapy:
    AZT is typically used in combination with other antiretroviral drugs to effectively manage HIV infection and prevent drug resistance. 
     
  • Side Effects:
    Common side effects include headaches, fever, and nausea. Serious side effects may include liver problems, muscle damage, and high blood lactate levels. 
     
  • History:
    AZT was the first drug approved for treating HIV/AIDS and was synthesized in 1964. 
     
  • Important Note:
    AZT does not cure or prevent HIV infection or AIDS, nor does it prevent the spread of the virus to others. 
     
  • Monitoring:
    Patients receiving AZT, especially in combination with other NRTIs, are monitored for viral load and other relevant markers to assess drug efficacy and adjust treatment if needed. 
     
 
  • Zidovudine - Wikipedia
    Zidovudine * Zidovudine (ZDV), also known as azidothymidine (AZT), was the first antiretroviral medication used to prevent and tr...
    Wikipedia
     
    金門美兆診  水針刀    AZT  ZDV  azidot
     
  • Antiretroviral Drug Discovery and Development | NIAID
    2024年2月5日 — AZT: The First Drug to Treat HIV Infection ... AZT proved ineffective against cancer and was shelved, but in the 1980s, i...
    National Institute of Allergy and Infectious Diseases (NIAID) (.gov)
     
    金門美兆診  水針刀    AZT  ZDV  azidot
     
  • AZT | HIV Treatment, Antiretroviral Drug - Britannica
    2025年5月16日 — Rare side effects of AZT include potentially life-threatening lactic acidosis (accumulation of lactic acid in body fluid...
    Britannica
     
    金門美兆診  水針刀    AZT  ZDV  azidot
     
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This is for informational purposes only. For medical advice or diagnosis, consult a professional. AI responses may include mistakes. Learn more
 
 
 
 
 
 
 
 
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