Azidothymidine (AZT), also known as zidovudine (ZDV), is an antiretroviral drug primarily used to treat and prevent HIV/AIDS. It works by inhibiting the reverse transcriptase enzyme, which HIV uses to replicate, thus decreasing the virus's replication rate.
Key points about azidothymidine:
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AZT is a nucleoside reverse transcriptase inhibitor (NRTI) that interferes with the HIV reverse transcriptase enzyme, halting the virus's ability to create new viral DNA.
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AZT is used to treat HIV infection and prevent the transmission of HIV from mother to child during pregnancy and birth. It can also be used after a needlestick injury or other potential exposure to HIV.
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AZT is typically used in combination with other antiretroviral drugs to effectively manage HIV infection and prevent drug resistance.
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Common side effects include headaches, fever, and nausea. Serious side effects may include liver problems, muscle damage, and high blood lactate levels.
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AZT was the first drug approved for treating HIV/AIDS and was synthesized in 1964.
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AZT does not cure or prevent HIV infection or AIDS, nor does it prevent the spread of the virus to others.
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Patients receiving AZT, especially in combination with other NRTIs, are monitored for viral load and other relevant markers to assess drug efficacy and adjust treatment if needed.
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